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Intrinsic network connectivity and affect dysregulation in depression

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Walter, M. (2017). Intrinsic network connectivity and affect dysregulation in depression. Journal of Neural Transmission, 124(10), 10-10.

Cite as: http://hdl.handle.net/21.11116/0000-0000-C544-5
Intrinsic network connectivity shows typical abnormalities in depression, which predispose individuals to respond differently to external contexts. Importantly abnormal reactivity can be characterised both blunted positive affect and increased negative affect. The latter is also related to abnormal duration of specific neuronal states following negative information. More recent research investigates such mechanisms in the context of dynamic connectivity elicited in rest-task-rest designs. We have established different cognitive and affective challenges under which specific dynamic changes of functional network connectivity is induced. Results show distinct dynamic profiles of dorsal and ventral posterior cingulate cortex as a main hub of a core network orchestrating reallocation of attentional resources. These mechanisms were shown to depend on subject characteristics including coping style and personality markers. In a clinical group of depressed patients, we found increased tonic reactivity towards attachment related stressors and in both patients and controls, dynamic state trajectories were accompanied by dynamic changes in EEG signatures concurrently recorded during fMRI.