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Decipher the hippocampal neurovascular coupling with simultaneous fMRI and GCaMP-mediated calcium recording

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/persons/resource/persons214920

Chen,  XM
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214924

Chen,  Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Chen, X., Chen, Y., & Yu, X. (2017). Decipher the hippocampal neurovascular coupling with simultaneous fMRI and GCaMP-mediated calcium recording. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017).


Cite as: http://hdl.handle.net/21.11116/0000-0000-C598-6
Abstract
Previously, we have developed a single-vessel fMRI method to visualize the hemodynamic signal propagation from individual venules and arterioles in the deep layer cortex and hippocampus. Here, we combined the single-vessel SSFP-fMRI with the GCaMP-mediated calcium recording to decipher the hippocampal neurovascular coupling events. Optogenetic stimulation led to epileptic activity, which could be detected as the bursting calcium spikes coupled to elongated fMRI signal from individual hippocampal arterioles and venules up to 20-30s following the epileptic events. This work establishes a multi-modal fMRI platform to characterize the hippocampal vascular dynamics of both normal and optogenetically driven seizure-like states.