GABA promotes beta-Amyloid related changes in dynamic network expression of 
elderly subjects at risk for Alzheimer's disease

Quevenco, F-C; Schreiner, S; Preti, MG; van Bergen, J; Kirchner, T; Wyss, M; Steininger, S; Gietl, A; Leh, S; Buck, A; Pruessman, K; Hock, C; Nitsch, R; Henning, A; Van de Ville, D; Unschuld, P

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GABA promotes beta-Amyloid related changes in dynamic network expression of elderly subjects at risk for Alzheimer's disease

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Henning, A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Quevenco, F.-C., Schreiner, S., Preti, M., van Bergen, J., Kirchner, T., Wyss, M., et al. (2017). GABA promotes beta-Amyloid related changes in dynamic network expression of elderly subjects at risk for Alzheimer's disease. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 668-668).

Cite as: https://hdl.handle.net/21.11116/0000-0000-C59C-2

Abstract

This study observes dynamic functional connectivity changes in an elderly AD-risk population mediated by both regional Aß-deposits and GABA levels, using PiB-PET and MRSI. The sample is grouped into subjects with high regional Aß and high GABA, and changes in dynamic network expression are compared between groups. Our preliminary findings show dynamic network changes specific to high Aß-deposits in the neocortex and the frontal and temporal lobe. This indicates region-specific network changes that may in part explain the weak correlation between global Aß and AD progression.