Cervical spinal cord and brain MRS alterations in normal appearing white matter 
of multiple sclerosis (MS) patients at 3T

Wyss, PO; Henning, A; Hock, A; Lutterotti, A; Martin, R; Kollias, S

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Cervical spinal cord and brain MRS alterations in normal appearing white matter of multiple sclerosis (MS) patients at 3T

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Wyss, PO
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Henning, A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Wyss, P., Henning, A., Hock, A., Lutterotti, A., Martin, R., & Kollias, S. (2017). Cervical spinal cord and brain MRS alterations in normal appearing white matter of multiple sclerosis (MS) patients at 3T. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 527-527).

Cite as: https://hdl.handle.net/21.11116/0000-0000-C5AA-2

Abstract

This investigation explores alterations of both cervical spinal cord and brain metabolite levels in normal appearing tissue in patients suffering from multiple sclerosis (MS). In the brain, a 2 dimensional J-resolved spectroscopy sequence and 2D prior-knowledge fitting is used and the metabolite cycling technique is applied to the cervical spinal cord at 3T. Relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) patients are included and alterations between brain and spinal cord metabolites are addressed.