T1ρ-weighted Dynamic Glucose Enhanced MRI

Schuenke, P; Paech, D; Koehler, C; Windschuh, J; Bachert, P; Ladd, M; Schlemmer, H-P; Radbruch, A; Zaiss, M

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T1ρ-weighted Dynamic Glucose Enhanced MRI

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Zaiss, M
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Schuenke, P., Paech, D., Koehler, C., Windschuh, J., Bachert, P., Ladd, M., et al. (2017). T1ρ-weighted Dynamic Glucose Enhanced MRI. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 517-517).

Cite as: https://hdl.handle.net/21.11116/0000-0000-C5B2-8

Abstract

Natural D-glucose can serve as a biodegradable contrast agent for the detection of tumors by means of Chemical Exchange Saturation Transfer (CEST) or Chemical Exchange sensitive Spin-Lock (CESL) Dynamic Glucose Enhanced (DGE) MRI. For application of CESL-based DGE-MRI at a 7T whole-body scanner, we implemented an adiabatic CESL sequence and essentially increased the temporal resolution employing a T1ρ-weighted acquisition scheme. Further, we introduced a simple, robust and quantitative DGE contrast. First application of T1ρ-weighted DGE-MRI in a glioblastoma patient provided a substantial contrast between tumor and healthy brain tissue and showed the dynamic glucose enhancement after a glucose bolus injection.