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Dynamic changes of glutamate detected by functional MR spectroscopy in human visual cortex in regions with positive and negative BOLD response

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Giapitzakis,  I
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Martínez-Maestro, M., Labadie, C., Giapitzakis, I., & Möller, H. (2017). Dynamic changes of glutamate detected by functional MR spectroscopy in human visual cortex in regions with positive and negative BOLD response. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 278-278).


Cite as: http://hdl.handle.net/21.11116/0000-0000-C5B6-4
Abstract
Dynamic changes of metabolite concentrations have been presented in human visual cortex in response to stimulus that induce a positive BOLD response (PBR). The present study compares the metabolic profile of the positive and the negative bold response (NBR). The application of different fMRS block designs showed a significant increase in Glutamate (+7.3) during the PBR stimulation paradigm in agreement with previous studies and a decrease (-6.6) during the NBR, which provides new information about its underlaying mechanisms.