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Functional Magnetic Resonance Spectroscopy (fMRS) using metabolite cycled semi-LASER at 9.4T: a pilot study

MPG-Autoren
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Giapitzakis,  IA
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Avdievitch,  N
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Manohar,  SM
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Henning,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Giapitzakis, I., Avdievitch, N., Manohar, S., Fichtner, N., Kreis, R., & Henning, A. (2017). Functional Magnetic Resonance Spectroscopy (fMRS) using metabolite cycled semi-LASER at 9.4T: a pilot study. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 277-277).


Zitierlink: https://hdl.handle.net/21.11116/0000-0000-C5B8-2
Zusammenfassung
The purpose of this work is to explore the potentials of fMRS under a visual stimulation at 9.4T using a metabolite cycled (MC) semi-LASER sequence. The MC technique allows for simultaneous acquisition of water and metabolite spectra enabling the synchronous investigation of dynamic alternations of BOLD signal and metabolite levels. Correlation of FWHMCr and FWHMNAA with SNRwater is demonstrated. The influence of misaligned subtraction is evaluated and the requirement of linewidth, frequency and phase-correction is highlighted. Finally, all previously reported alterations of upfield metabolites are confirmed and for first time also potential difference of downfield metabolites are observed.