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Simultaneous fMRI with GCaMP6-mediated neuronal and astrocytic calcium signal recording

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/persons/resource/persons214940

Wang,  M
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192829

He,  Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Wang, M., He, Y., & Yu, X. (2017). Simultaneous fMRI with GCaMP6-mediated neuronal and astrocytic calcium signal recording. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 122-122).


Cite as: http://hdl.handle.net/21.11116/0000-0000-C5C0-8
Abstract
Neurovascular coupling is the basis of the BOLD fMRI, however, the mechanisms of the neurovascular coupling remains elusive. By simultaneous cell-type specific Ca2+ recording with BOLD fMRI, it allowed us to study the cellular specific coupling events through the neuron-glia-vessel network. This work showed neuronal Ca2+ and evoked astrocytic Ca2+ signal were positively correlated to the fMRI signal, but an intrinsic astrocytic Ca2+ signal was negatively correlated to the fMRI signal in the cortex. It indicated a novel neuron-glia-vascular coupling event mediated through the intrinsic astrocytic calcium signal (details mechanistic study in another abstract: ID 4475).