日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細


公開

会議抄録

Persistent Long-term Impairment of Cardiac Energetics after Tako-tsubo Cardiomyopathy

MPS-Authors
/persons/resource/persons84402

Henning,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

Link
(全文テキスト(全般))

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
フルテキスト (公開)
公開されているフルテキストはありません
付随資料 (公開)
There is no public supplementary material available
引用

Scally, C., Rudd, A., Ahearn, T., Maclennan, B., Wilson, H., Broadhurst, P., Henning, A., & Dawson, D. (2017). Persistent Long-term Impairment of Cardiac Energetics after Tako-tsubo Cardiomyopathy. In 20th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance (SCMR 2017) (pp. 185-185).


引用: https://hdl.handle.net/21.11116/0000-0000-C602-E
要旨
Background: Tako-tsubo cardiomyopathy is an acute form of left ventricular (LV) systolic dysfunction triggered by intense emotional/physical stress. We have previously demonstrated that Tako-tsubo is characterized by profound cardiac energetic impairment with incomplete recovery at short term follow-up (4 months). Due to the persistence of symptoms in a majority of patients, we further hypothesised that impaired cardiac energetics continues during long-term follow-up (> 1 year). Methods: Sixteen patients [all women, median age 68 years (range 44-81)] with a previously clearly demonstrated diagnosis of Tako-tsubo were invited from the Aberdeen Tako-tsubo registry and 10 healthy volunteers [(all women, median age 62 years (range 44-72)] were recruited from the Cardiology Healthy Volunteer Database. All subjects underwent 31P-Cardiac Magnetic Resonance Spectroscopy (31P-CMRS) and cardiac imaging on a 3T Philips scanner (Best, The Netherlands). 31P-CMRS was analysed with JMRUi-3 (University of Lyon, France) to derive calculation of the Phosphocreatine/Gamma Adenosine Triphosphate (PCr/ATP) ratio as the gold-standard in vivo assessment of cardiac energetics. Standard cardiac analysis was performed using CMRTools (Cardiovascular Solutions, London, UK). All subjects underwent clinical interview [Minnesota Living with Heart Failure questionnaire (MLWHFQ)] to establish cardiac symptoms. Results: All but one of the 16 patients complained of ongoing symptoms (chest pain, breathlessness, fatigue) since the acute Takotsubo event (mean MLWHFQ score 14.6). Median follow-up was 23 months (range 13-39 months). There was no significant difference between the previous Tako-tsubo sufferers and the healthy volunteers with respect to their indexed LV volumes (end-systolic: 27.9± 9.9mls/m2 vs 25.2±4.6mls/m2, p=0.6, end-diastolic: 73.9±15.4 mls/m2 vs 74.2±6.9mls, p=0.9) or LV mass (67±9.1g/m2 vs 65±6.8g, p=0.7) or LV Ejection fraction 62±9.3 vs 65.9±4.3 p=0.2. The resting cardiac energetic status (PCr/ATP ratio) was significantly decreased in Tako-tsubo patients compared with healthy volunteers: 1.3 ± 0.7 vs.1.9 ± 0.5, p=0.03. Conclusions: The ongoing symptoms in patients who experienced an acute Tako-tsubo episode at least one year previously is accompanied by significant cardiac energetic impairment.