Sequence and functional expression of the GABAA receptor shows a ligand-gated 
receptor super-family

Schofield, Peter R.; Darlison, Mark G.; Fujita, Norihisa; Rodriguez, Henry F.; Burt, David R.; Stephenson, Anne; Rhee, Lucy M.; Ramachandran, J.; Glencorse, Thora A.; Reale, Vincenzina; Seeburg, Peter H.; Barnard, Eric A.

doi:10.1038/328221a0

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Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Schofield, P. R., Darlison, M. G., Fujita, N., Rodriguez, H. F., Burt, D. R., Stephenson, A., et al. (1987). Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature, 328(6127), 221-227. doi:10.1038/328221a0.

Cite as: https://hdl.handle.net/21.11116/0000-0000-C8E9-8

Abstract

Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.