Molecular distinction between fetal and adult forms of muscle acetylcholine 
receptor

Mishina, Masayoshi; Takai, T.; Imoto, K.; Noda, M.; Takahashi, Tomoyuki; Numa, Shosaku; Methfessel, Christoph; Sakmann, Bert

doi:10.1038/321406a0

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Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

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Sakmann, Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Mishina, M., Takai, T., Imoto, K., Noda, M., Takahashi, T., Numa, S., et al. (1986). Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature, 321(6068), 406-411. doi:10.1038/321406a0.

Cite as: https://hdl.handle.net/21.11116/0000-0000-CCFB-0

Abstract

Distinct classes of acetylcholine receptor channels are formed when Xenopus oocytes are injected with combinations of the bovine alpha-, beta-, gamma- and delta- or the alpha-, beta-, gamma- and epsilon-subunit-specific messenger RNAs. The conductance and gating properties of the two classes of channels, in conjunction with the developmental changes in the muscular contents of the mRNAs, suggest that replacement of the gamma-subunit by the epsilon-subunit is responsible for the functional alteration of the receptor during muscle development.