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Journal Article

Functional insights into pathogen biology from 3D electron microscopy

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Kudryashev,  Misha       
Sofja Kovalevskaja Group, Max Planck Institute of Biophysics, Max Planck Society;
Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt;

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Citation

Cyrklaff, M., Frischknecht, F., & Kudryashev, M. (2017). Functional insights into pathogen biology from 3D electron microscopy. FEMS Microbiology Reviews, 41(6), 828-853. doi:10.1093/femsre/fux041.


Cite as: https://hdl.handle.net/21.11116/0000-0001-27E1-5
Abstract
In recent years, novel imaging approaches revolutionised our understanding of the cellular and molecular biology of microorganisms. These include advances in fluorescent probes, dynamic live cell imaging, super resolution light and electron microscopy. Currently, a major transition in the experimental approach shifts electron microscopy studies from a complementary technique to a method of choice for structural and functional analysis. Here we review functional insights into the molecular architecture of viruses, bacteria and parasites as well as interactions with their respective host cells gained from studies using cryogenic electron tomography and related methodologies.