A prolactin-inhibiting factor within the precursor for human 
gonadotropin-releasing hormone

Nikolics, Károly; Mason, Anthony J.; Szonyi, Éva; Ramachandran, J.; Seeburg, Peter H.

doi:10.1038/316511a0

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A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Nikolics, K., Mason, A. J., Szonyi, É., Ramachandran, J., & Seeburg, P. H. (1985). A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone. Nature, 316, 511-517. doi:10.1038/316511a0.

Cite as: https://hdl.handle.net/21.11116/0000-0000-CF02-5

Abstract

The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino acid GnRH-associated peptide (GAP). GAP was found to be a potent inhibitor of prolactin secretion and to stimulate the release of gonadotropins in rat pituitary cell cultures. Active immunization with peptides corresponding to GAP sequences led to greatly increased prolactin secretion in rabbits.