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Di–tert–butyl N,N-diethylphosphoramidite as an Air Stable Ligand for Suzuki-Miyaura and Buchwald-Hartwig Reactions

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/persons/resource/persons137019

Ilie,  Adriana
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität, Fachbereich Chemie, Marburg, Germany;

/persons/resource/persons58934

Roiban,  Georghe-Doru
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität, Fachbereich Chemie, Marburg, Germany;
GlaxoSmithKline plc, Medicines Research Centre, Hertfordshire, U.K;

/persons/resource/persons58919

Reetz,  Manfred T.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität, Fachbereich Chemie, Marburg, Germany;

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Citation

Ilie, A., Roiban, G.-D., & Reetz, M. T. (2017). Di–tert–butyl N,N-diethylphosphoramidite as an Air Stable Ligand for Suzuki-Miyaura and Buchwald-Hartwig Reactions. ChemistrySelect, 2(4), 1392-1397. doi:10.1002/slct.201700086.


Cite as: https://hdl.handle.net/21.11116/0000-0000-D097-A
Abstract
We describe herein an air stable phosphorus ligand for both Suzuki-Miyaura and Buchwald-Hartwig palladium-catalyzed cross coupling reactions. The versatility of the Pd(dba)2-di-tert-butyl N,N-diethylphosphoramidite catalytic system is demonstrated for a variety of aryl and heteroaryl halides. This ligand is "bench stable" which allows easy catalyst preparation. Moreover, even at low catalyst loadings (0.5 %), excellent yields are usually achieved.