Role of acetylcholine receptor subunits in gating of the channel

Sakmann, Bert; Methfessel, Christoph; Mishina, Masayoshi; Takahashi, Tomoyuki; Takai, T.; Kurasaki, M.; Fukuda, K.; Numa, Shosaku

doi:10.1038/318538a0

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Role of acetylcholine receptor subunits in gating of the channel

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Sakmann, Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Sakmann, B., Methfessel, C., Mishina, M., Takahashi, T., Takai, T., Kurasaki, M., et al. (1985). Role of acetylcholine receptor subunits in gating of the channel. Nature, 318, 539-543. doi:10.1038/318538a0.

Cite as: https://hdl.handle.net/21.11116/0000-0000-D357-0

Abstract

The Torpedo and calf acetylcholine receptors and hybrids composed of subunits from the two species have been produced in Xenopus oocytes by the use of the cloned complementary DNAs. Single-channel current measurements indicate that these receptors form channels of similar conductance but with different gating behaviour.