Ether Synthesis through Reductive Cross-Coupling of Ketones with Alcohols Using 
Me2SiHCl as both Reductant and Lewis Acid

Lee, Yong Ho; Morandi, Bill

doi:10.1055/s-0036-1590838

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Ether Synthesis through Reductive Cross-Coupling of Ketones with Alcohols Using Me₂SiHCl as both Reductant and Lewis Acid

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Lee, Yong Ho
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Morandi, Bill
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Lee, Y. H., & Morandi, B. (2017). Ether Synthesis through Reductive Cross-Coupling of Ketones with Alcohols Using Me₂SiHCl as both Reductant and Lewis Acid. Synlett, 28(18), 2425-2428. doi:10.1055/s-0036-1590838.

Cite as: https://hdl.handle.net/21.11116/0000-0000-FA88-D

Abstract

We report that a Lewis acidic silane, Me₂SiHCl, can mediate the direct cross-coupling of a wide range of carbonyl compounds with alcohols to form dialkyl ethers. The reaction is operationally simple, tolerates a range of polar functional groups, can be utilized to make sterically hindered ethers, and is extendable to sulfur and nitrogen nucleophiles.