The impact of white matter hyperintensities on brain functional connectivity in 
amnestic mild cognitive impairment patients

Torso, M; Mastropasqua, C; Giulietti, G; Serra, L; Olivito, G; Tuzzi, Elisa; Spanò, B; Caltagirone, C; Cercignani, M; Bozzali, M

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The impact of white matter hyperintensities on brain functional connectivity in amnestic mild cognitive impairment patients

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http://www.ismrm.org/15/program_files/TueEPS04.htm
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Torso, M., Mastropasqua, C., Giulietti, G., Serra, L., Olivito, G., Tuzzi, E., et al. (2015). The impact of white matter hyperintensities on brain functional connectivity in amnestic mild cognitive impairment patients. Poster presented at 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.

Cite as: https://hdl.handle.net/21.11116/0000-0000-F22B-F

Abstract

In this study we used resting state f-MRI to investigate the contribution of White Matter Hyperintensities (WMHs) in determining functional connectivity (FC) changes in amnestic Mild Cognitive Impairment patients, the prodromal stage of Alzheimer disease. WMHs volumes were quantified by semiautomatic method on TSE images and used to distinguish patients in two different groups (high WMHs volume –H and low WMHs volume –L). The main finding of the study was that a higher WMHs volume can determine changes in FC and that these alterations are associated with the presence of cognitive deficits in the patients.