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Journal Article

mRNA transport & local transaltion in neurons

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Glock, Caspar
Max Planck Institute for Brain Research, Max Planck Society;

Heumüller, Maximilian
Max Planck Institute for Brain Research, Max Planck Society;

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Citation

Glock, C., Heumüller, M., & Schuman, E. M. (2017). mRNA transport & local transaltion in neurons. Current Opinion in Neurbiology, 45, 169-177. doi:10.1016/j.conb2017.05.005.

Abstract

Neurons are among the most structurally complex cells and exhibit a high degree of spatial compartmentalization. Also, neurons exhibit rapid and dynamic signaling by processing information in a precise and, sometimes, spatially-restricted manner. The signaling that occurs in axons and dendrites necessistates the maintenance and modification of their local proteomes. Local translation of mRNAs into protein is one solution tha neurons use to meet synaptic demand and activity. Here we review some of the key findings and recent discoveries that have shaped our understanding of local tanslation in neuronal function and highlight important new techniques htat might pave the way for new insights.