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Journal Article

Local translation in neuronal compartments: how local is loca?

MPS-Authors

Rangaraju,  Vidhya
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

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tom Dieck,  Susanne
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Schuman,  Erin M
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

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Citation

Rangaraju, V., tom Dieck, S., & Schuman, E. M. (2017). Local translation in neuronal compartments: how local is loca? EMBO Reports, 18(5), 693. doi:10.15252/embr201744045.


Cite as: http://hdl.handle.net/21.11116/0000-0000-F58A-0
Abstract
Efficient neuronal function depdends on the continued modulation of the local neuronal proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at specific neuronal regions. Various aspects of translation such as the localizatin of translational machinery, spatial spread of the newly translated proteins, and their site of action are carried out in specialized neuronal subcompartments such as size, biochemical and organelle composition, structural boundaries, and temporal dynamics. We also discuss the apparent absence of definitive components of translation in these local compartments and the emerging state-of-the-art tools that could help dissecting these conunbrums in greater detail in the future