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Journal Article

Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

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Hyman,  Tony
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Weishaupt, J. H., Hyman, T., & Dikic, I. (2016). Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Trends in Molecular Medicine, 22(9), 769-783.


Cite as: https://hdl.handle.net/21.11116/0000-0001-02A5-2
Abstract
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative diseases in which predominantly motor neurons and cerebral cortex neurons, respectively, are affected. Several novel ALS and FTD disease genes have been recently discovered, pointing toward a few overarching pathways in ALS/FTD pathogenesis. Nevertheless, a precise picture of how various cellular processes cause neuronal death, or how different routes leading to ALS and FTD are functionally connected is just emerging. Moreover, how the most recent milestone findings in the ALS/FTD field might lead to improved diagnosis and treatment is actively being explored. We highlight some of the most exciting recent topics in the field, which could potentially facilitate the identification of further links between the pathogenic ALS/FTD pathways related to autophagy, vesicle trafficking, and RNA metabolism.