Proteome-wide dataset supporting the study of ancient metazoan macromolecular 
complexes.

Phanse, Sadhna; Wan, Cuihong; Borgeson, Blake; Tu, Fan; Drew, Kevin; Clark, Greg; Xiong, Xuejian; Kagan, Olga; Kwan, Julian; Bezginov, Alexandr; Chessman, Kyle; Pal, Swati; Cromar, Graham; Papoulas, Ophelia; Ni, Zuyao; Boutz, Daniel R; Stoilova, Snejana; Havugimana, Pierre C; Guo, Xinghua; Malty, Ramy H; Sarov, Mihail; Greenblatt, Jack; Babu, Mohan; Derry, W Brent; Tillier, Elisabeth R; Wallingford, John; Parkinson, John; Marcotte, Edward M; Emili, Andrew

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Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes.

MPS-Authors

Drew, Kevin
Max Planck Society;

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Sarov, Mihail
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Wallingford, John
Max Planck Society;

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Citation

Phanse, S., Wan, C., Borgeson, B., Tu, F., Drew, K., Clark, G., et al. (2016). Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Data in Brief, 6, 715-721.

Cite as: https://hdl.handle.net/21.11116/0000-0001-034B-8

Abstract

Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. The interaction network obtained from the data was validated globally in 4 distant species (Xenopus laevis, Nematostella vectensis, Dictyostelium discoideum, Saccharomyces cerevisiae) and locally by targeted affinity-purification experiments. Here we provide details of our massive set of supporting biochemical fractionation data available via ProteomeXchange (PXD002319-PXD002328), PPIs via BioGRID (185267); and interaction network projections via (http://metazoa.med.utoronto.ca) made fully accessible to allow further exploration. The datasets here are related to the research article on metazoan macromolecular complexes in Nature [1].