English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver.

MPS-Authors
/persons/resource/persons219807

Zerial,  Marino
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Yin, H., Bogorad, R. L., Barnes, C., Walsh, S., Zhuang, I., Nonaka, H., et al. (2016). RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver. Journal of Hepatology, 64(4), 899-907.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0359-8
Abstract
The Hippo pathway controls organ size through a negative regulation of the transcription co-activator Yap1. The overexpression of hyperactive mutant Yap1 or deletion of key components in the Hippo pathway leads to increased organ size in different species. Analysis of interactions of this pathway with other cellular signals corroborating organ size control is limited in part due to the difficulties associated with development of rodent models.