Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Intracellular Scaling Mechanisms.


Reber,  Simone
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;


Goehring,  Nathan
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Reber, S., & Goehring, N. (2015). Intracellular Scaling Mechanisms. Cold Spring Harbor Perspectives in Biology, 7(12): a019067.

Cite as: https://hdl.handle.net/21.11116/0000-0001-045A-6
Organelle function is often directly related to organelle size. However, it is not necessarily absolute size but the organelle-to-cell-size ratio that is critical. Larger cells generally have increased metabolic demands, must segregate DNA over larger distances, and require larger cytokinetic rings to divide. Thus, organelles often must scale to the size of the cell. The need for scaling is particularly acute during early development during which cell size can change rapidly. Here, we highlight scaling mechanisms for cellular structures as diverse as centrosomes, nuclei, and the mitotic spindle, and distinguish them from more general mechanisms of size control. In some cases, scaling is a consequence of the underlying mechanism of organelle size control. In others, size-control mechanisms are not obviously related to cell size, implying that scaling results indirectly from cell-size-dependent regulation of size-control mechanisms.