Another Brick in the Wall: RNAi Screens Identify New Barriers in iPSC 
Reprogramming.

Winzi, M; Paszkowski-Rogacz, Maciej; Buchholz, Frank

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Another Brick in the Wall: RNAi Screens Identify New Barriers in iPSC Reprogramming.

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Paszkowski-Rogacz, Maciej
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Buchholz, Frank
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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引用

Winzi, M., Paszkowski-Rogacz, M., & Buchholz, F. (2014). Another Brick in the Wall: RNAi Screens Identify New Barriers in iPSC Reprogramming. Cell Stem Cell, 15(2), 116-118.

引用: https://hdl.handle.net/21.11116/0000-0001-052E-7

要旨

Somatic cells can be reprogrammed to induced pluripotent stem cells via exogenous expression of a small set of transcription factors, but the regulatory mechanisms controlling this cell transition are poorly understood. Two recent reports demonstrate the value of RNAi screens as a tool to uncover roadblocks in this inefficient process.