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morFeus: a web-based program to detect remotely conserved orthologs using symmetrical best hits and orthology network scoring.

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Wagner,  Ines
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Volkmer,  Michael
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Oswald,  Felix
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Surendranath,  Vineeth
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Habermann,  Bianca
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Wagner, I., Volkmer, M., Sharan, M., Villaveces, J. M., Oswald, F., Surendranath, V., et al. (2014). morFeus: a web-based program to detect remotely conserved orthologs using symmetrical best hits and orthology network scoring. BMC Bioinformatics, 15: 263.


Cite as: https://hdl.handle.net/21.11116/0000-0001-05BC-6
Abstract
Searching the orthologs of a given protein or DNA sequence is one of the most important and most commonly used Bioinformatics methods in Biology. Programs like BLAST or the orthology search engine Inparanoid can be used to find orthologs when the similarity between two sequences is sufficiently high. They however fail when the level of conservation is low. The detection of remotely conserved proteins oftentimes involves sophisticated manual intervention that is difficult to automate.