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Journal Article

Regulation of β-cell function by RNA-binding proteins.


Magro,  Maria Grazia
Max Planck Society;


Solimena,  Michele
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Magro, M. G., & Solimena, M. (2013). Regulation of β-cell function by RNA-binding proteins. Molecular Metabolism, 2(4), 348-355.

Cite as: https://hdl.handle.net/21.11116/0000-0001-0740-F
β-cells of the pancreatic islets are highly specialized and high-throughput units for the production of insulin, the key hormone for maintenance of glucose homeostasis. Elevation of extracellular glucose and/or GLP-1 levels triggers a rapid upregulation of insulin biosynthesis through the activation of post-transcriptional mechanisms. RNA-binding proteins are emerging as key factors in the regulation of these mechanisms as well as in other aspects of β-cell function and glucose homeostasis at large, and thus may be implicated in the pathogenesis of diabetes. Here we review current research in the field, with a major emphasis on RNA-binding proteins that control biosynthesis of insulin and other components of the insulin secretory granules by modulating the stability and translation of their mRNAs.