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Journal Article

Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain

MPS-Authors

Graupner,  Sylvi
Max Planck Society;

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Tanaka,  Elly M.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Funk,  Richard
Max Planck Society;

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Huttner,  Wieland B.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Brand,  Michael
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Corbeil,  Denis
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Jászai, J., Graupner, S., Tanaka, E. M., Funk, R., Huttner, W. B., Brand, M., et al. (2013). Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain. PLoS ONE, 8(5): e63457.


Cite as: https://hdl.handle.net/21.11116/0000-0001-074E-1
Abstract
In mammals, embryonic neural progenitors as well as adult neural stem cells can be prospectively isolated based on the cell surface expression of prominin-1 (CD133), a plasma membrane glycoprotein. In contrast, characterization of neural progenitors in non-mammalian vertebrates endowed with significant constitutive neurogenesis and inherent self-repair ability is hampered by the lack of suitable cell surface markers. Here, we have investigated whether prominin-1-orthologues of the major non-mammalian vertebrate model organisms show any degree of conservation as for their association with neurogenic geminative zones within the central nervous system (CNS) as they do in mammals or associated with activated neural progenitors during provoked neurogenesis in the regenerating CNS.