English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Spatial organization of the cell cytoplasm by position-dependent phase separation.

MPS-Authors
/persons/resource/persons219034

Brangwynne,  Clifford
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Gharakhani,  Joebin
Max Planck Society;

/persons/resource/persons219253

Hyman,  Anthony
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Lee, C. F., Brangwynne, C., Gharakhani, J., Hyman, A., & Jülicher, F. (2013). Spatial organization of the cell cytoplasm by position-dependent phase separation. Physical Review Letters, 111(8): 088101.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0750-D
Abstract
During asymmetric cell division, cytoplasmic components are segregated to opposite sides of the cell. We discuss how the observed segregation can be achieved by a position-dependent phase separation mechanism controlled by a protein concentration gradient. We show that effects of even a weak gradient can be amplified by the phase transition to achieve strong segregation. We compare our theory to the segregation of germ granules observed during the divisions in the C. elegans embryo. Our study demonstrates how liquid-liquid phase separation can play a key role in the organization of the cytoplasm.