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Journal Article

Breathe in and straighten your back: hypoxia, notch, and scoliosis

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Bajard,  Lola
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Oates,  Andrew C.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Bajard, L., & Oates, A. C. (2012). Breathe in and straighten your back: hypoxia, notch, and scoliosis. Cell, 149(2), 255-256.


Cite as: https://hdl.handle.net/21.11116/0000-0001-07E2-8
Abstract
In this issue of Cell, Sparrow et al. propose a new mechanism for sporadically occurring congenital scoliosis in which Notch signaling and hypoxia converge in the embryo on somite patterning via the segmentation clock. This interaction between hypoxia and a predisposed genetic background might underlie other birth defects with incomplete penetrance.