English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions.

MPS-Authors
/persons/resource/persons219360

Kurzchalia,  Teymuras V.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Schneider, K., Köcher, T., Andersin, T., Kurzchalia, T. V., Schibler, U., & Gatfield, D. (2012). CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions. EMBO Reports, 13(12), 1138-1144.


Cite as: https://hdl.handle.net/21.11116/0000-0001-07E6-4
Abstract
In mammals, transcriptional autorepression by Period (PER) and Cryptochrome (CRY) protein complexes is essential for the generation of circadian rhythms. We have identified CAVIN-3 as a new, cytoplasmic PER2-interacting protein influencing circadian clock properties. Thus, CAVIN-3 loss- and gain-of-function shortened and lengthened, respectively, the circadian period in fibroblasts and affected PER:CRY protein abundance and interaction. While depletion of protein kinase Cδ (PKCδ), a known partner of CAVIN-3, had little effect on circadian gene expression, CAVIN-3 required the PKCδ-binding site to exert its effect on period length. This suggests the involvement of yet uncharacterized protein kinases. Finally, CAVIN-3 activity in circadian gene expression was independent of caveolae.