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Journal Article

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.

MPS-Authors
/persons/resource/persons219150

Fava,  Eugenio
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Ouwendijk,  Joke
Max Planck Society;

/persons/resource/persons219486

Niederlein,  Antje
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219761

Verkade,  Paul
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219677

Solimena,  Michele
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Fava, E., Dehghany, J., Ouwendijk, J., Müller, A., Niederlein, A., Verkade, P., et al. (2012). Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. Diabetologia, 55(4), 1013-1023.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0878-0
Abstract
Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.