English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Penetration of amphiphilic quantum dots through model and cellular plasma membranes

MPS-Authors
/persons/resource/persons86719

Sezgin,  Erdinc
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons15815

Schwille,  Petra
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Eychmüller,  Alexander
Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Dubavik, A., Sezgin, E., Lesnyak, V., Gaponik, N., Schwille, P., & Eychmüller, A. (2012). Penetration of amphiphilic quantum dots through model and cellular plasma membranes. ACS Nano, 6(3), 2150-2156.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0888-D
Abstract
In this work we demonstrate progress in the colloidal synthesis of amphiphilic CdTe nanocrystals stabilized by thiolated PEG oligomers with the aim of facilitating cellular uptake of the particles. High-boiling, good coordinating solvents such as dimethylacetamide and dimethylformamide accelerate the growth of the nanoparticles yielding stable colloids of which photoluminescence maxima can be tuned to cover the region of 540-640 nm with quantum yields of up to 30%. The CdTe nanocrystals capped by thiolated methoxypolyethylene glycol are shown to penetrate through the lipid bilayer of giant unilamellar vesicles and giant plasma membrane vesicles which constitute basic endocytosis-free model membrane systems. Moreover, the penetration of amphiphilic particles through live cell plasma membranes and their ability to escape the endocytic pathway have been demonstrated.