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Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice.

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Schuhmann,  Kai
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Herzog,  Ronny
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Shevchenko,  Andrej
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Fernandez, C., Schuhmann, K., Herzog, R., Fielding, B., Frayn, K., Shevchenko, A., et al. (2011). Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice. PLoS ONE, 6(6): e21603.


Cite as: http://hdl.handle.net/21.11116/0000-0001-09B2-C
Abstract
Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored lipids, thus mobilizing fatty acids. HSL exhibits broad substrate specificity and besides acylglycerides it hydrolyzes cholesteryl esters, retinyl esters and lipoidal esters. Despite its role in fatty acid mobilization, HSL null mice have been shown to be resistant to diet-induced obesity. The aim of this study was to define lipid profiles in plasma, white adipose tissue (WAT) and liver of HSL null mice, in order to better understand the role of this multifunctional enzyme.