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Journal Article

Molecular convergence of bacterial and eukaryotic surface order.

MPS-Authors
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Kaiser,  Hermann-Josef
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Surma,  Michal
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219383

Levental,  Ilya
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons137687

Grzybek,  Michal
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219318

Klemm,  Robin W.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219389

Lingwood,  Daniel
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219671

Simons,  Kai
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Kaiser, H.-J., Surma, M., Levental, I., Grzybek, M., Klemm, R. W., Lingwood, D., et al. (2011). Molecular convergence of bacterial and eukaryotic surface order. Journal of Biological Chemistry, 286(47), 40631-40637.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0A66-2
Abstract
The conservation of fluidity is a theme common to all cell membranes. In this study, an analysis of lipid packing was conducted via C-laurdan spectroscopy of cell surface membranes prepared from representative species of Bacteria and Eukarya. We found that despite their radical differences in composition (namely the presence and absence of membrane-rigidifying sterol) the membrane order of all taxa converges on a remarkably similar level. To understand how this similarity is constructed, we reconstituted membranes with either bacterial or eukaryotic components. We found that transmembrane segments of proteins have an important role in buffering lipid-mediated packing. This buffering ensures that sterol-free and sterol-containing membranes exhibit similar barrier properties.