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Journal Article

Multi-talented MCAK: Microtubule depolymerizer with a strong grip.

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Diez,  Stefan
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Diez, S. (2011). Multi-talented MCAK: Microtubule depolymerizer with a strong grip. Nature Cell Biology, 13(7), 738-740.


Cite as: http://hdl.handle.net/21.11116/0000-0001-0A6A-E
Abstract
Microtubule-depolymerizing motor proteins regulate microtubule dynamics during chromosome segregation, but whether they can independently grip the ends of shrinking kinetochore microtubules has remained unresolved. MCAK, a member of the kinesin-13 motor protein family, is now shown to grip microtubules on its own and harness the forces of microtubule disassembly.