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Mechanics and remodelling of cell packings in epithelia.

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Röper,  Jens-Christian
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Aigouy,  Benoit
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Eaton,  Suzanne
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Staple, D. B., Farhadifar, R., Röper, J.-C., Aigouy, B., Eaton, S., & Jülicher, F. (2010). Mechanics and remodelling of cell packings in epithelia. The European Physical Journal. E, Soft Matter, 33(2), 117-127.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0BB9-3
Abstract
Epithelia are sheets of cells that are dynamically remodelled by cell division and cell death during development. Here we describe the cell shapes and packings as networks of polygons: stable and stationary network configurations obey force balance and are represented as local minima of a potential function. We characterize the physical properties of this vertex model, including the set of ground states, and the energetics of topological rearrangements. We furthermore discuss a quasistatic description of cell division that allows us to study the mechanics and dynamics of tissue remodelling during growth. The biophysics of cells and their rearrangements can account for the morphology of cell packings observed in experiments.