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Journal Article

Tamoxifen-independent recombination in the RIP-CreER mouse.

MPS-Authors
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Liu,  Yanmei
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Suckale,  Jakob
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Magro,  Maria Grazia
Max Planck Society;

Steffen,  Anja
Max Planck Society;

Anastassiadis,  Konstantinos
Max Planck Society;

/persons/resource/persons219677

Solimena,  Michele
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Liu, Y., Suckale, J., Masjkur, J., Magro, M. G., Steffen, A., Anastassiadis, K., et al. (2010). Tamoxifen-independent recombination in the RIP-CreER mouse. PLoS ONE, 5(10): e13533.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0C3B-1
Abstract
The inducible Cre-lox system is a valuable tool to study gene function in a spatial and time restricted fashion in mouse models. This strategy relies on the limited background activity of the modified Cre recombinase (CreER) in the absence of its inducer, the competitive estrogen receptor ligand, tamoxifen. The RIP-CreER mouse (Tg (Ins2-cre/Esr1) 1Dam) is among the few available β-cell specific CreER mouse lines and thus it has been often used to manipulate gene expression in the insulin-producing cells of the endocrine pancreas.