English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

The elegans of spindle assembly.

MPS-Authors
/persons/resource/persons219471

Müller-Reichert,  Thomas
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219201

Greenan,  Garrett
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

O'Toole,  Eileen T.
Max Planck Society;

/persons/resource/persons219686

Srayko,  Martin
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Müller-Reichert, T., Greenan, G., O'Toole, E. T., & Srayko, M. (2010). The elegans of spindle assembly. Cellular and Molecular Life Sciences: CMLS, 67(13), 2195-2213.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0C49-1
Abstract
The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1 h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce the replicated maternal diploid set of chromosomes to a single-copy haploid set. The resulting maternal DNA then unites with the paternal DNA to form a zygotic diploid complement, around which a centrosome-based mitotic spindle forms. The early C. elegans embryo is amenable to live-cell imaging and electron tomography, permitting a detailed structural comparison of the meiotic and mitotic modes of spindle assembly.