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The elegans of spindle assembly.

MPS-Authors
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Müller-Reichert,  Thomas
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Greenan,  Garrett
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

O'Toole,  Eileen T.
Max Planck Society;

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Srayko,  Martin
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Müller-Reichert, T., Greenan, G., O'Toole, E. T., & Srayko, M. (2010). The elegans of spindle assembly. Cellular and Molecular Life Sciences: CMLS, 67(13), 2195-2213.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0C49-1
Abstract
The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1 h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce the replicated maternal diploid set of chromosomes to a single-copy haploid set. The resulting maternal DNA then unites with the paternal DNA to form a zygotic diploid complement, around which a centrosome-based mitotic spindle forms. The early C. elegans embryo is amenable to live-cell imaging and electron tomography, permitting a detailed structural comparison of the meiotic and mitotic modes of spindle assembly.