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Journal Article

Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA.


Gentzel,  Marc
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Feike, A. C., Rachor, K., Gentzel, M., & Schambony, A. (2010). Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA. Biochemical and Biophysical Research Communications, 400(4), 500-506.

Cite as: http://hdl.handle.net/21.11116/0000-0001-0C6F-7
Ror receptor-tyrosine kinases act as Wnt-5a receptors in beta-catenin independent Wnt-signaling pathways. In Xenopus, expression of xPAPC is regulated by a Wnt-5a/Ror2 pathway, which resembles typical signaling cascades downstream of receptor-tyrosine kinases. Here, we have identified the phospho-tyrosine binding protein ShcA as an intracellular binding partner of Ror2. ShcA binds to a conserved motif in Ror2 via its SH2-domain. Wnt-5a induces clustering of Ror2 in the cell membrane and recruitment of ShcA to the Ror2 receptor complex. We further show that ShcA is co-expressed with Ror2 in developing Xenopus embryos and ShcA is required for Wnt-5a/Ror2 mediated upregulation of xPAPC, demonstrating the functional relevance of this interaction.