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Morphological homeostasis by autophagy

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/persons/resource/persons219389

Lingwood,  Daniel
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Schuck,  Sebastian
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Ferguson,  Charles
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Gerl,  Mathias
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219671

Simons,  Kai
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Lingwood, D., Schuck, S., Ferguson, C., Gerl, M., & Simons, K. (2009). Morphological homeostasis by autophagy. Autophagy, 5(7), 1039-1040.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0D4B-E
Abstract
With cellular organelles coming in all shapes and sizes, the principle 'form follows function' is readily discernible through the cytologist's lens. Architecturally, one might ask whether there is feedback in this organization. Does a cell 'know' when it has constructed membrane into the stacks of the Golgi, the cisternae of the mitochondria or the tubules of the endoplasmic reticulum? Proofreading can occur in vivo as both errors in nucleic acids and misfolds in proteins are recognized by the cell. Are there analogous systems which maintain/regulate the architectural integrity of organelles? Our recent paper entitled Generation of cubic membranes from controlled homotypic interactions of membrane proteins in the endoplasmic reticulum suggests that autophagy may play such a role.