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Journal Article

Blebs lead the way: how to migrate without lamellipodia

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Paluch,  Ewa
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Charras, G., & Paluch, E. (2008). Blebs lead the way: how to migrate without lamellipodia. Nature Reviews. Molecular Cell Biology, 9(9), 730-736.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0DE4-0
Abstract
Blebs are spherical membrane protrusions that are produced by contractions of the actomyosin cortex. Blebs are often considered to be a hallmark of apoptosis; however, blebs are also frequently observed during cytokinesis and during migration in three-dimensional cultures and in vivo. For tumour cells and a number of embryonic cells, blebbing migration seems to be a common alternative to the more extensively studied lamellipodium-based motility. We argue that blebs should be promoted to a more prominent place in the world of cellular protrusions.