Retromer retrieves Wntless

Eaton, Suzanne

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Retromer retrieves Wntless

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Eaton, Suzanne
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Eaton, S. (2008). Retromer retrieves Wntless. Developmental Cell, 14(1), 4-6.

Cite as: https://hdl.handle.net/21.11116/0000-0001-0E7F-3

Abstract

Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.