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The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size

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Müller-Reichert,  Thomas
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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引用

Song, M. H., Aravind, L., Müller-Reichert, T., & O'Connell, K. F. (2008). The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Developmental Cell, 15(6), 901-912.


引用: http://hdl.handle.net/21.11116/0000-0001-0EAE-D
要旨
Microtubules are organized by the centrosome, a dynamic organelle that exhibits changes in both size and number during the cell cycle. Here we show that SZY-20, a putative RNA-binding protein, plays a critical role in limiting centrosome size in C. elegans. SZY-20 localizes in part to centrosomes and in its absence centrosomes possess increased levels of centriolar and pericentriolar components including gamma-tubulin and the centriole duplication factors ZYG-1 and SPD-2. These enlarged centrosomes possess normal centrioles, nucleate more microtubules, and fail to properly direct a number of microtubule-dependent processes. Depletion of ZYG-1 restores normal centrosome size and function to szy-20 mutants, whereas loss of szy-20 suppresses the centrosome duplication defects in both zyg-1 and spd-2 mutants. Our results describe a pathway that determines centrosome size and implicate centriole duplication factors in this process.