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Book Chapter

Models of hair cell mechanotransduction

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Bechstedt,  Susanne
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Howard,  Jonathon
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Bechstedt, S., & Howard, J. (2007). Models of hair cell mechanotransduction. In O. P. Hamill (Ed.), Mechanosensitive ion channels, Vol. 59, Pt. B (pp. 399-424). Amsterdam: Elsevier.


Cite as: https://hdl.handle.net/21.11116/0000-0001-0F5E-7
Abstract
Hair cell mechanotransduction is based on a finely tuned machinery residing in the hair bundle, the hair cell’s receptive organelle. The machinery consists of a transduction channel, an adaptation motor, the tip link, and many other components that reside in the stereocilia. The transduction channel is connected to and opened by a gating spring for which there are several molecular candidates. The interplay between the motor, the spring, the channel, and the tip link assures that the channel is always working at its most sensitive point of this machine, allowing very fast responses to a force stimulus. This chapter addresses the mechanisms and molecular components underlying mechanotransduction, adaptation, and motility in the hair bundle.