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Journal Article

Controversy fuels trafficking of GPI-anchored proteins

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Schuck,  Sebastian
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Simons,  Kai
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Schuck, S., & Simons, K. (2006). Controversy fuels trafficking of GPI-anchored proteins. Journal of Cell Biology, 172(7), 963-965.


Cite as: https://hdl.handle.net/21.11116/0000-0001-1025-3
Abstract
The model that glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) take a direct transport route to the apical membrane of epithelial cells has recently been challenged. In this issue, Paladino et al. (p. 1023) and Hua et al. (p. 1035) show that the original view nevertheless holds. This closes a chapter in the winding story of GPI-AP trafficking but opens another phase, as the controversy has stimulated the development of new methodology.