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Journal Article

Parallel Manipulation of Bifunctional DNA Molecules on Structured Surfaces Using Kinesin-Driven Microtubules

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Dinu,  Cerasela Zoica
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Howard,  Jonathon
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219112

Diez,  Stefan
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Dinu, C. Z., Opitz, J., Pompe, W., Howard, J., Mertig, M., & Diez, S. (2006). Parallel Manipulation of Bifunctional DNA Molecules on Structured Surfaces Using Kinesin-Driven Microtubules. Small, 2(8-9), 1090-1098.


Cite as: https://hdl.handle.net/21.11116/0000-0001-1078-6
Abstract
We have developed a technique to manipulate bifunctional DNA molecules: One end is thiolated to bind to a patterned gold surface and the other end is biotinylated to bind to a microtubule gliding over a kinesin-coated surface. We found that DNA molecules can be stretched and overstretched between the gold pads and the motile microtubules, and that they can form dynamic networks. This serves as a proof-ofprinciple that biological machineries can be used in vitro to accomplish the parallel formation of structured DNA templates that will have applications in biophysics and nanoelectronics.