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Journal Article

SAS-4 is a C-elegans centriolar protein that controls centrosome size

MPS-Authors
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Kirkham,  M.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Müller-Reichert,  T.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Oegema,  K.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Grill,  S.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Hyman,  A. A.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Kirkham, M., Müller-Reichert, T., Oegema, K., Grill, S., & Hyman, A. A. (2003). SAS-4 is a C-elegans centriolar protein that controls centrosome size. Cell, 112(4), 575-587.


Cite as: https://hdl.handle.net/21.11116/0000-0001-1292-5
Abstract
Centrosomes consist of a centriole pair surrounded by pericentriolar material (PCM). Previous work suggested that centrioles are required to organize PCM to form a structurally stable organelle. Here, we characterize SAS-4, a centriole component in Caenorhabditis elegans. Like tubulin, SAS-4 is incorporated into centrioles during their duplication and remains stably associated thereafter. In the absence of SAS-4, centriole duplication falls. Partial depletion of SAS-4 results in structurally defective centrioles that contain reduced levels of SAS-4 and organize proportionally less PCM. Thus, SAS-4 is a centriole-associated component whose amount dictates centrosome size. These results provide novel insight into the poorly understood role of centrioles as centrosomal organizers.