Stretching and Transporting DNA Molecules Using Motor Proteins

Diez, Stefan; Reuther, Cordula; Dinu, Cerasela; Seidel, Ralf; Mertig, Michael; Pompe, Wolfgang; Howard, Jonathon

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Stretching and Transporting DNA Molecules Using Motor Proteins

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Diez, Stefan
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Reuther, Cordula
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Dinu, Cerasela
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Seidel, Ralf
Max Planck Society;

Mertig, Michael
Max Planck Society;

Pompe, Wolfgang
Max Planck Society;

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Howard, Jonathon
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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引用

Diez, S., Reuther, C., Dinu, C., Seidel, R., Mertig, M., Pompe, W., & Howard, J. (2003). Stretching and Transporting DNA Molecules Using Motor Proteins. Nano Letters, 3(9), 1251-1254.

引用: https://hdl.handle.net/21.11116/0000-0001-12FA-1

要旨

Inside cells, motor proteins perform a variety of complex tasks including the transport of vesicles and the separation of chromosomes. We demonstrate a novel use of such biological machines for the mechanical manipulation of nanostructures in a cell-free environment. Specifically, we show that purified kinesin motors in combination with chemically modified microtubules can transport and stretch individual -phage DNA molecules across a surface. This technique, in contrast to existing ones, enables the parallel yet individual manipulation of many molecules and may offer an efficient mechanism for assembling multidimensional DNA structures.