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The distribution of active force generators controls mitotic spindle position.

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Grill,  Stephan W
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Howard,  Jonathon
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Schaffer,  Erik
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Stelzer,  Ernst H K
Max Planck Society;

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Hyman,  Anthony A
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Grill, S. W., Howard, J., Schaffer, E., Stelzer, E. H. K., & Hyman, A. A. (2003). The distribution of active force generators controls mitotic spindle position. Science, 301(5632), 518-521.


Cite as: http://hdl.handle.net/21.11116/0000-0001-1300-9
Abstract
During unequal cell divisions a mitotic spindle is eccentrically positioned before cell cleavage. To determine the basis of the net force imbalance that causes spindle displacement in one-cell Caenorhabditis elegans embryos, we fragmented centrosomes with an ultraviolet laser. Analysis of the mean and variance of fragment speeds suggests that the force imbalance is due to a larger number of force generators pulling on astral microtubules of the posterior aster relative to the anterior aster. Moreover, activation of heterotrimeric guanine nucleotide- binding protein (Gprotein) alpha subunits is required to generate these astral forces.