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Journal Article

The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation.

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Kilian,  Beate
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Mansukoski,  Hannu
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Ulrich,  Florian
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219231

Heisenberg,  Carl Philipp
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Kilian, B., Mansukoski, H., Barbosa, F. C., Ulrich, F., Tada, M., & Heisenberg, C. P. (2003). The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mechanisms of Development, 120(4), 467-476.


Cite as: https://hdl.handle.net/21.11116/0000-0001-130C-D
Abstract
Wnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation. The analysis of ppt mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent extension movements in posterior regions of the gastrula, while its function in more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5 in this process. The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements.